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Caspases Group III, Active Human

based on 2 citations in multiple journalsCaspases Group III, Active Human24.1 4
Set of recombinant proteases involved in apoptosis
Catalog #: K243
$425.00

Product Details

Cat # +Size K243-4-25
Size 4 x 25 units
Gene Symbol CASP6 CASP8 CASP9 CASP10
Gene ID CASP6- 839CASP8- 841CASP9- 842CASP10- 843
Accession # CASP6- P55212CASP8- Q14790CASP9- P55211CASP10- Q92851
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized powder
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The Group III recombinant caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VEID-pNA (for caspase-6), IETD-pNA (for caspase-8 & -10) and LEHD-pNA (for caspase-9), respectively.


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Caudron-Herger et al., Dissecting the nascent human transcriptome by analysing the RNA content of transcription factories. Nucleic Acids Res., Aug 2015; 43: e95.
Cheng F. et. al. The Capsid Proteins of Aleutian Mink Disease Virus Activate Caspases and Are Specifically Cleaved during Infection J. Virol., Mar 2010; 84: 2687 - 2696.
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