Product Details
| Alternate Name | Z-VAD-FMK, Z-VAD fluoromethylketone, Caspase-Family Inhibitor, pan-caspase inhibitor |
|---|---|
| Peptide Sequence | Z-Val-Ala-Asp(OMe)-FMK |
| Appearance | Liquid |
| Formulation | 1010-100 In DMSO (2 mM); 1010-20C In DMSO (10 mM) |
| CAS # | 187389-52-2 |
| Molecular Formula | C₂₂H₃₀N₃O₇F |
| Molecular Weight | 467.5 |
| Purity | Single spot by TLC |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31) |
| InChi Key | MIFGOLAMNLSLGH-UHFFFAOYSA-N |
| PubChem CID | 5737 |
| MDL Number | MFCD01074990 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used in both in vitro and in vivo studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
Aurélie S. Leroyer et al., The Involvement of CD146 and Its Novel Ligand Galectin-1 in Apoptotic Regulation of Endothelial Cells. J. Biol. Chem., Jan 2013; 288: 2571 - 2579
Liu J et al (2009) Infect. Immun.; 77: 837 - 849.
Dai Y et al (2008) Clin. Cancer Res.; 14: 7701 - 7710.
Liu J et al (2008) Infect. Immun. 76: 3784-3792.
Arai S et al. (2007) PNAS 104: 2289-2294.
For more citations of this product click here
