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Caspase-Family Inhibitor Z-VAD-FMK

based on 12 citations in multiple journalsCaspase-Family Inhibitor Z-VAD-FMK124.6 5
Caspase family Inhibitor
Catalog #: 1010
SKU-Size Size Price Qty
1010-20C 20 µl (10 mM)
$135.00
1010-100 100 µl (2 mM)
$135.00
More Sizes Get Quote

Product Details

Alternate Name Z-VAD-FMK, Z-VAD fluoromethylketone, Caspase-Family Inhibitor, pan-caspase inhibitor
Peptide Sequence Z-Val-Ala-Asp(OMe)-FMK
Appearance Liquid
Formulation 1010-100 In DMSO (2 mM); 1010-20C In DMSO (10 mM)
CAS # 187389-52-2
Molecular Formula C₂₂H₃₀N₃O₇F
Molecular Weight 467.5
Purity Single spot by TLC
SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)
InChi Key MIFGOLAMNLSLGH-UHFFFAOYSA-N
PubChem CID 5737
MDL Number MFCD01074990
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used in both in vitro and in vivo studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Aurélie S. Leroyer  et al., The Involvement of CD146 and Its Novel Ligand Galectin-1 in Apoptotic Regulation of Endothelial Cells. J. Biol. Chem., Jan 2013; 288: 2571 - 2579
Liu J et al (2009) Infect. Immun.; 77: 837 - 849.
Dai Y et al (2008) Clin. Cancer Res.; 14: 7701 - 7710.
Liu J et al (2008) Infect. Immun. 76: 3784-3792.
Arai S et al. (2007) PNAS 104: 2289-2294.
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