Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Caspase-9, human recombinant

based on 8 citations in multiple journalsCaspase-9, human recombinant84.1 4
An aspartic acid protease involved in apoptosis 
Catalog #: 1089
SKU-Size Size Price Qty
1089-25 25 units
$215.00
1089-100 100 units
$370.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, LEHDase
Gene Symbol CASP9
Gene ID 842
Accession # P55211
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Semi Dry powder
Purity by SDS-PAGE ≥90%
Reconstitution Instructions Reconstitute to 1 unit per μl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-9 is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-9 also exists in cells as an inactive proenzyme. During the initiation of apoptosis procaspase-9 is processed at aspartate residues to form active caspase-9. As one of the initiator caspases, active caspase-9 functions to trigger activation of downstream effector caspases, leading to disassembly of cell structures. The recombinant active human caspase-9 was expressed in E. coli. The active caspase-9 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-LEHD-pNA (Cat. #1076-200) or Ac-LEHD-AFC (1075-200).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Han et a., A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. J. Biol. Chem., Mar 2014; 289: 6485 - 6497.
Xia et al., Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells. J. Biol. Chem., Jul 2013; 288: 19321 - 19329.
Murakami, E. et. al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J. Biol. Chem., Nov 2010; 285: 34337 - 34347.
Bian, Y. et al. Neuregulin-1 Attenuated Doxorubicin-Induced Decrease in Cardiac Troponins. Am. J. Physiol. Heart Circ. Physiol. 2009; 297: H1974-H1983.
Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
For more citations of this product click here