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Caspase-9 Antibody

based on 3 citations in multiple journalsCaspase-9 Antibody34.1 4
Catalog #: 3016
SKU-Size Size Price Qty
3016-30T 30 µg
$89.00
3016-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-9
Alternate Name CASP-9 , EC 3.4.22.62 , ICE-like apoptotic protease 6 ,ICE-LAP6 ,Apoptotic protease Mch-6 ,Apoptotic protease-activating factor 3 , Apaf-3
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 290 of human caspase-9
Accession # RP11-265F14.3
Gene ID 842
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
Purification Affinity purified
Species Reactivity Human, mouse, rat, hamster, bovine, rabbit, pig
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects proform (~46 kDa), intermediate (~33-36 kDa), and the fully cleaved (~20-25 kDa) caspase-9.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase-9 is one of the most important caspases among the caspase family members. Caspase-9 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis. The processed caspase-9 consists of large (32-35 kD) and small (10 kD) subunits which associate to form an active enzyme. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.


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Jiang, Pengfei et al. (2016) A potential molecular model for studying apoptosis enhanced by the interaction of BCL-G with JAB1 in swine, Oncotarget. 2016 Sep 27;7(39):62912-62924.
Woods CG et al. (2007) Toxicol Sci. 98: 366-374.
Takebe, N., et al. (2006) Mol. Cancer Ther. 5: 457-466.
Siu, P. M., et al. (2005) J. Physiol. 565: 309-323.
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