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Caspase-9 Antibody

based on 1 citations in multiple journalsCaspase-9 Antibody14.1 4
Catalog #: 3409
SKU-Size Size Price Qty
3409-30T 30 µg
$89.00
3409-100 100 µg
$245.00
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Product Details

Antibody Target Caspase-9
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 345 of mouse caspase-9
Accession # CAM23133
Gene ID 12371
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) protein A purified rabbit anti-caspase-9 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Mouse small intestine and rat kidney tissue lysates can be used as positive controls. The antibody detects 45 kDa procaspase-9, 35/37 kDa cleaved large frag
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase-9 is one of the most important caspases among the caspase family members. Upon induction of apoptosis, cytochrome c released from mitochondria associates with procaspase-9/Apaf-1. The complex processes procaspase-9 into a large subunit (35 kDa or 17 kDa) and small (10 kDa) by self-cleavage at D315. Activated caspase-9 further cleaves other caspase members including caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. In addition to self-cleavage, procaspase-9 can also be cleaved in vivo by caspase-3 at D330. The process served as a positive feedback to amplify the apoptotic signal in caspase activation pathway.


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Woods CG et al. (2007) Toxicol Sci. 98: 366-374.
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