Caspase-8 Substrate IETD-pNA

A Caspase-8 substrate
Catalog #: 1063 | abID:

Product Details

Alternate Name Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
Peptide Sequence Ac-Ile-Glu-Thr-Asp-pNA
Appearance Liquid
Formulation DMSO (4 mM)
Molecular Formula C₂₇H₃₈N₆O₁₂
Molecular Weight 638.6
Purity >95% by HPLC
InChi InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
PubChem CID 25108782
MDL Number MFCD01318840
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.

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