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Caspase-8 Substrate IETD-pNA

based on 14 citations in multiple journalsCaspase-8 Substrate IETD-pNA144.6 4.8
A Caspase-8 substrate
Catalog #: 1063
SKU-Size Size Price Qty
1063-200 200 assays
$255.00
1063-1000 1000 assays
$545.00
More Sizes Get Quote

Product Details

Alternate Name Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
Peptide Sequence Ac-Ile-Glu-Thr-Asp-pNA
Appearance Liquid
Formulation DMSO (4 mM)
Molecular Formula C₂₇H₃₈N₆O₁₂
Molecular Weight 638.6
Purity >95% by HPLC
SMILES CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C
InChi InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
InChi Key FHURKTIGZAIQGR-BQCLNCLCSA-N
PubChem CID 25108782
MDL Number MFCD01318840
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.


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Ishdorj G et al (2008) J.Biol. Chem. 283: 16818-16829.
Yuan S et al (2008) FASEB j. 10.1096/FJ.08-107417.
Lee S-Y et al. (2007) Infect Immun. 75: 1291-1302.
Lieman, J.H., et al. (2005) J. Biol. Chem. 10.1074/jbc.M409371200.
Collin C., et al. (2001) J. Biol. Chem. 276:37602-37611.
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