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Product Details
| Alternate Name | Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric |
|---|---|
| Peptide Sequence | Ac-Ile-Glu-Thr-Asp-pNA |
| Appearance | Liquid |
| Formulation | DMSO (4 mM) |
| Molecular Formula | C₂₇H₃₈N₆O₁₂ |
| Molecular Weight | 638.6 |
| Purity | >95% by HPLC |
| SMILES | CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C |
| InChi | InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1 |
| InChi Key | FHURKTIGZAIQGR-BQCLNCLCSA-N |
| PubChem CID | 25108782 |
| MDL Number | MFCD01318840 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.
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Yuan S et al (2008) FASEB j. 10.1096/FJ.08-107417.
Lee S-Y et al. (2007) Infect Immun. 75: 1291-1302.
Lieman, J.H., et al. (2005) J. Biol. Chem. 10.1074/jbc.M409371200.
Collin C., et al. (2001) J. Biol. Chem. 276:37602-37611.
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