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Caspase-8, mouse recombinant

A cysteine-aspartic acid protease involved in apoptosis
Catalog #: 1188
SKU-Size Size Price Qty
1188-100 100 units
$285.00
1188-25 25 units
$145.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Gene Symbol CASP8
Gene ID 12370
Accession # Q3U607
Source E. coli
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Active caspase-8 has been shown to activate caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active mouse caspase-8 was expressed in E. coli. The active caspase-8 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).


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