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Caspase-8, human recombinant

based on 6 citations in multiple journalsCaspase-8, human recombinant64.1 4
A cysteine-aspartic acid protease involved in apoptosis
Catalog #: 1088
SKU-Size Size Price Qty
1088-25 25 units
$215.00
1088-100 100units
$370.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog
Gene Symbol CASP8
Gene ID 841
Accession # Q14790
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-8 (also know as FLICE, MASH, Mch5) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis procaspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-8 consists of large and small subunits which associate to form the active enzyme. Active caspase-8 has been shown to activate caspase-3 leading to degradation of a variety of cellular target proteins during apoptosis. The recombinant active human caspase-8 was expressed in E. coli. The active caspase-8 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).


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Shresh Pathak, Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro. JCI Insight., Feb. 2020;  32051334.
Avinash Appukuttan et al., Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion, Cardiovasc Res, Feb 2012; 93: 340 - 349.
Murakami, E. et. al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J. Biol. Chem., Nov 2010; 285: 34337 - 34347.
Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
Sone K et al (2008) Genes Cells 13: 771 - 785.
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