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Caspase-8 Antibody (Clone C502S)

based on 4 citations in multiple journalsCaspase-8 Antibody (Clone C502S)44.1 4
Catalog #: 3258
$365.00

Product Details

Cat # +Size 3258-100
Size 100 µg
Antibody Target Caspase-8 (Active)
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Synthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8
Accession # BC006737
Gene ID 12370
Appearance Colorless liquid
Concentration 0.2 μg/ml
Formulation 100 µg (200 µg/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation
Application & Usage Western blotting (0.5-4 µg/ml) and immunoprecipitation (10 µg/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.


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Mahul-Mellier A-L et al (2008) J. Biol. Chem.; 283: 34954-34965.
Pattison JS et al (2008) Circulation 117: 2743 - 2451.
Scarabelli, T.M. et al. (2004) J. Thorac. Cardiovasc. Surg. 128: 364-371.
Scarabelli, T.M. et al. (2002) Circ. Res. 90:745-748.
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