Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Caspase-8 Antibody (Clone C502S)

based on 4 citations in multiple journalsCaspase-8 Antibody (Clone C502S)44.1 4
Catalog #: 3258

Product Details

Cat # +Size 3258-100
Size 100 µg
Antibody Target Caspase-8 (Active)
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Synthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8
Accession # BC006737
Gene ID 12370
Appearance Colorless liquid
Concentration 0.2 μg/ml
Formulation 100 µg (200 µg/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation
Application & Usage Western blotting (0.5-4 µg/ml) and immunoprecipitation (10 µg/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Mahul-Mellier A-L et al (2008) J. Biol. Chem.; 283: 34954-34965.
Pattison JS et al (2008) Circulation 117: 2743 - 2451.
Scarabelli, T.M. et al. (2004) J. Thorac. Cardiovasc. Surg. 128: 364-371.
Scarabelli, T.M. et al. (2002) Circ. Res. 90:745-748.
For more citations of this product click here