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Caspase-8 Antibody

based on 5 citations in multiple journalsCaspase-8 Antibody54.1 4
Catalog #: 3020
SKU-Size Size Price Qty
3020-30T 30 µg
$89.00
3020-100 100 µg
$275.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-8
Alternate Name CASP8 , MGC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC 3.4.22.61
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 392 of mouse caspase-8
Accession # BC006737
Gene ID 12370
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 0.5 mg/ml in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
Purification Affinity purified
Species Reactivity mouse, rat, bovine, monkey
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). The immunoaffinity purified antibody detects the full length (55 kDa), intermediate cleavage fragments (26-31 kDa) and cleaved large fragment (18 kDa) of caspase-8.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.


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Mahul-Mellier A-L et al (2008) J. Biol. Chem.; 10.1074/jbc.M803140200.
Pelufo MC et al. (2007) Am J. Physiol Endocrinol. Metab. 293: E1215-E1223
Woods CG et al. (2007) Toxicol Sci. 98: 366-374.
Peluffo M.C. et al. (2006) Reproduction 132: 465-475.
Sasaki M. et al. (2006) Am. J. Path. 169: 831-845.
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