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Caspase-8 Antibody

based on 2 citations in multiple journalsCaspase-8 Antibody24.1 4
Catalog #: 3158
SKU-Size Size Price Qty
3158-30T 30 µg
$89.00
3158-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-8
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding the cleavage site of human Caspase-8
Accession # ABX09989
Gene ID 841
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-caspase-8 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunohistochemistry
Application & Usage Western blotting (0.5-4 µg/ml) and in Immunohistochemistry (10-20 mg/ml). ). However, the optimal conditions should be determined individually. The affinity purified antibody mainly detects the 26 kDa fully cleaved fragment and the 35-43 kDa intermediate
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.


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Mahul-Mellier A-L et al (2008) J. Biol. Chem.; 10.1074/jbc.M803140200.
Woods CG et al. (2007) Toxicol Sci. 98: 366-374.
For more citations of this product click here