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Caspase-8 (Active) Antibody

based on 4 citations in multiple journalsCaspase-8 (Active) Antibody44.1 4
Catalog #: 3259
SKU-Size Size Price Qty
3259-30T 30 µg
$89.00
3259-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-8 (Active)
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding amino acid 392 of mouse caspase-8
Accession # BC006737
Gene ID 12370
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in PBS containing 50% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml) in samples from mouse and rat origins. However, the optimal conditions should be determined individually. The antibody detects the 25 kDa large subunit of caspase-8. It does not detect the full-length of caspase-8.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.


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Tikano, J. et. al. Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival. Mol. Cell. Biol., Oct 2011; 31: 4097 - 4106.
Mahul-Mellier A-L et al (2008) J. Biol. Chem.; 283: 34954 - 34965.
Pattison JS et al (2008) Circulation 117: 2743 - 2451.
Woods CG et al. (2007) Toxicol. Sci. 98: 366 - 374.
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