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Product Details
| Alternate Name | Ac-VEID-AFC, Caspase-6 Substrate, Fluorogenic, VEID-AFC |
|---|---|
| Peptide Sequence | Ac-Val-Glu-Ile-Asp-AFC |
| Appearance | Liquid |
| Formulation | DMSO ( 1 mM) |
| Molecular Formula | C₃₂H₄₀F₃N₅O₁₁ |
| Molecular Weight | 727.7 |
| Purity | >95% by HPLC |
| SMILES | CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C |
| InChi | InChI=1S/C32H40F3N5O11/c1-6-15(4)27(40-28(47)20(9-10-23(42)43)38-30(49)26(14(2)3)36-16(5)41)31(50)39-21(13-24(44)45)29(48)37-17-7-8-18-19(32(33,34)35)12-25(46)51-22(18)11-17/h7-8,11-12,14-15,20-21,26-27H,6,9-10,13H2,1-5H3,(H,36,41)(H,37,48)(H,38,49)(H,39,50)(H,40,47)(H,42,43)(H,44,45) |
| InChi Key | RPBOFHGWCDGAEG-UHFFFAOYSA-N |
| PubChem CID | 44135099 |
| MDL Number | MFCD01318833 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Ready-to-use fluorometric substrate for caspase-6 and related caspases that recognize the amino acid sequence VEID. Caspase-6 and related caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the peptide substrate VEID-AFC at Ex/Em = 400/505, using a fluorometer or multi-well fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized, using a hand-held long-UV lamp. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase-6 assays. Cell Lysis Buffer (Cat. #1067-100, -400) and 2X Reaction Buffer (Cat. #1068-20, -80) for caspase assays are also available separately.
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Bai, S., et al. (2004) Am. Cancer Ther. 3:613-620.
Deane, A, Jennifer., et al. (2004) J. Immunol. 172:6615-6625.
Coletti, D., et al. (2002) EMBO J. 21:631-642.
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