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Caspase-5 Substrate WEHD-pNA

based on 2 citations in multiple journalsCaspase-5 Substrate WEHD-pNA24.1 4
A caspase-5 substrate
Catalog #: 1102
SKU-Size Size Price Qty
1102-200 200 assays
$255.00
1102-1000 1000 assays
$565.00
More Sizes Get Quote

Product Details

Alternate Name Ac-WEHD-pNA, Caspase-5 Substrate, Colorimetric
Peptide Sequence Ac-Trp-Glu-His-Asp-pNA
Appearance Liquid
Formulation DMSO (4 mM)
Molecular Formula C₃₄H₃₇N₉O₁₁
Molecular Weight 747.7
Purity >99% by HPLC
SMILES CC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CN=CN3)C(=O)NC(CC(=O)O)C(=O)NC4=CC=C(C=C4)[N+](=O)[O-]
InChi InChI=1S/C34H37N9O11/c1-18(44)38-26(12-19-15-36-24-5-3-2-4-23(19)24)33(51)40-25(10-11-29(45)46)31(49)41-27(13-21-16-35-17-37-21)34(52)42-28(14-30(47)48)32(50)39-20-6-8-22(9-7-20)43(53)54/h2-9,15-17,25-28,36H,10-14H2,1H3,(H,35,37)(H,38,44)(H,39,50)(H,40,51)(H,41,49)(H,42,52)(H,45,46)(H,47,48)
InChi Key FDGCMTAKGVLJGO-UHFFFAOYSA-N
PubChem CID 44135315
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ready-to-use colorimetric substrate for caspase-5 and related caspases that recognize the amino acid sequence WEHD. Caspase-5 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleaved from the peptide substrate WEHD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large volume of caspase assays.


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Oh, H. A. et. al. Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro. J. Pharmacol. Exp. Ther., Oct 2011; 339: 72 - 81.
Doostzadeh J., et al. (2000) J. Biol. Chem. 275:25336-25341.
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