Product Details
| abID | ab142027 |
|---|---|
| Alternate Name | Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone) |
| Peptide Sequence | Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK |
| Appearance | Liquid |
| Formulation | 1100-100 In DMSO (2 mM); 1100-20C In DMSO (10 mM) |
| Molecular Formula | C₃₇H₄₂FN₇O₁₀ |
| Molecular Weight | 763.78 |
| Purity | >99% by HPLC |
| SMILES | COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4 |
| InChi | InChI=1S/C37H42FN7O10/c1-53-32(47)13-12-27(34(49)44-30(15-24-19-39-21-41-24)36(51)43-28(31(46)17-38)16-33(48)54-2)42-35(50)29(14-23-18-40-26-11-7-6-10-25(23)26)45-37(52)55-20-22-8-4-3-5-9-22/h3-11,18-19,21,27-30,40H,12-17,20H2,1-2H3,(H,39,41)(H,42,50)(H,43,51)(H,44,49)(H,45,52) |
| InChi Key | NLZNSSWGRVBWIX-UHFFFAOYSA-N |
| PubChem CID | 44134610 |
| MDL Number | MFCD03453283 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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What is the Cas number of Z-WEHD-FMK?
Cas number is 210345-00-9.
Youn Jung Choi, SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol., Jan 2019; 30692621.
Burm et al., Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases. J. Neurosci., Jan 2015; 35: 678 - 687.
Gillet, L. (2005) Cancer Res. 65: 9463-9472.
Coletti, D., et al. (2002) EMBO J. 21:631-642.
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