Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Caspase-5, human recombinant

based on 3 citations in multiple journalsCaspase-5, human recombinant34.1 4
A cysteine protease involved in apoptosis 
Catalog #: 1085
SKU-Size Size Price Qty
1085-25 25 units
$205.00
1085-100 100 units
$350.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY
Gene Symbol CASP5
Gene ID 838
Accession # P51878
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-5 (also know as ICErelIII, TY) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-5 exists in cells as an inactive proenzyme which is matured by proteolysis to yield large and small subunits. The active caspase-5 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-5 activation and roles of caspase-5 in apoptosis are poorly understood. The recombinant active human caspase-5 was expressed in E. coli. The active caspase-5 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-WEHD-pNA (Cat. #1102-200) or Ac-WEHD-AFC (1101-200).


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Shresh Pathak, Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro. JCI Insight., Feb. 2020;  32051334.
Murakami, E. et. al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J. Biol. Chem., Nov 2010; 285: 34337 - 34347.
Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
Hasegawa H et al. (2007) Blood 110: 1664-1674.
For more citations of this product click here