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Caspase-5 Antibody

based on 1 citations in multiple journalsCaspase-5 Antibody14.1 4
Catalog #: 3029
SKU-Size Size Price Qty
3029-30T 30 µg
$89.00
3029-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-5
Alternate Name CASP-5, ICH-3 protease, TY protease, ICH3
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acids 162 of human caspase-5
Accession # NP_004338
Gene ID 838
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat, monkey, hamster, bovine
Application Western blot
Application & Usage Western blotting (0.5-4ag/ml). However, the optimal conditions should be determined individually. The affinity purified antibody preferentially detects the intermediate (32 kDa) and the fully (20 kDa) cleaved caspase-5.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-5 is also known as Ich-3 and ICErel-III and can proteolytically processed by granzyme B. Over expression of caspase-5 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.


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Bian. Z-M et. al. Expression and Functional Roles of Caspase-5 in Inflammatory Responses of Human Retinal Pigment Epithelial Cells. Invest. Ophthalmol. Vis. Sci., Nov 2011; 52: 8646 - 8656.
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