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Caspase-4 Inhibitor Z-LEVD-FMK

based on 6 citations in multiple journalsCaspase-4 Inhibitor Z-LEVD-FMK64.1 4
A caspase-4 inhibitor
Catalog #: 1108
SKU-Size Size Price Qty
1108-20C 20 µl (10 mM)
1108-100 100 µl (2 mM)
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Product Details

Alternate Name Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Appearance Liquid
Formulation 1108-100 In DMSO (2 mM); 1108-20C In DMSO (10 mM)
Molecular Formula C₃₁H₄₅FN₄O₁₀
Molecular Weight 652.7
Purity >95% by HPLC
InChi InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)
PubChem CID 44135220
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A synthetic peptide inhibitor that inhibits caspase-4 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

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Peng Yin, Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol., Feb. 2019;  30810811.
Akamatsu K et al (2009) Anticancer Res; 29: 2195-2204.
Jian CC et al (2009) Carcinogenesis; 30: 197 - 204.
Chen LH et al. (2008) Cancer Res. 68: 834 - 842.
Jiang CC et al. (2007) Cancer Res.67: 9750-9761.
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