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Active Recombinant Human Caspase-4

based on 4 citations in multiple journalsActive Recombinant Human Caspase-444.1 4
A cysteine protease involved in apoptosis 
Catalog #: 1084
SKU-Size Size Price Qty
1084-25 25 units
$215.00
1084-100 100 units
$370.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-4, CASP-4, ICE(rel)-II, Protease ICH-2, Protease TX
Gene Symbol CASP4
Gene ID 837
Accession # P49662
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Reconstitute to 1 unit per µl in distilled H2O
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-4 (also know as Ich-4, ICErelII, TX) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-4 exists in cells as an inactive proenzyme which is matured by proteolysis to yield large and small subunits. The active caspase-4 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-4 activation and roles of caspase-4 in apoptosis are poorly understood. The recombinant active human caspase-4 was expressed in E. coli. The active caspase-4 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-WEHD-pNA (Cat. #1102-200) or Ac-WEHD-AFC (1101-200).


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Shresh Pathak, Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro. JCI Insight., Feb. 2020;  32051334.
Xia et al., Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells. J. Biol. Chem., Jul 2013; 288: 19321 - 19329.
Murakami, E. et. al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J. Biol. Chem., Nov 2010; 285: 34337 - 34347.
Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
Hasegawa H et al. (2007) Blood 110: 1664-1674.
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