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Caspase-3 Inhibitor Z-DEVD-FMK

based on 14 citations in multiple journalsCaspase-3 Inhibitor Z-DEVD-FMK144.6 5
Caspase-3 inhibitor
Catalog #: 1009

In stock

SKU-Size Size Price Qty
1009-20C 20 µl (10 mM)
$135.00
1009-100 100 µl (2 mM)
$135.00
More Sizes Get Quote

Product Details

Alternate Name Z-DEVD-FMK, Caspase-3 inhibitor, Z-DEVD fluoromethylketone
Peptide Sequence Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Appearance Liquid
Formulation 1009-100 In DMSO (2 mM); 1009-20C In DMSO (10 mM)
Molecular Formula C₃₀H₄₁FN₄O₁₂
Molecular Weight 668.7
Purity >98% by HPLC
SMILES CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChi Key GBJVAVGBSGRRKN-JYEBCORGSA-N
PubChem CID 16760394
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Kim Sung-Jo et al.(2006) Hum. Mol. Genet. 15: 1826-1834.
Lin T-N. et al. (2006) Arterioscler. Thromb. Vasc. Biol. 26: 481-487.
Ma, Y., et al. (2006) J. Cell Biol. 175: 209-215.
Mao W. et al. (2006) Am. J. Physiol. Cell Physiol. 290: C1373-C1384.
Bi, Y., et al., (2005) J. Biol. Chem. 280: 30481-30489..Deng X. et al. (2006) Toxicol. Sci. 91: 59 - 69.
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