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Product Details
| Antibody Target | Caspase-3 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide corresponding to the C-terminus of caspase-3 large fragment |
| Accession # | P42574 |
| Gene ID | 836 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 0.5 mg/ml affinity purified rabbit anti-caspase-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA, 0.03% Proclin |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects proform and the cleaved large fragment of caspase-3. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-3 is synthesized as an inactive pro-enzyme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP and DFF).
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Matsuda, N. et al. Increased Death Receptor Pathway of Apoptotic Signaling in Septic Mouse Aorta: Effect of Systemic Delivery of FADD siRNA. Am. J. Physiol. Heart Circ. Physiol. 2010; 298: H92-H101.
Matsuda N et al (2009) Am. J. Respir. Crit. Care Med.; 10.1164/rccm.200804-534OC.
Turpin S et al (2009) J. Physiol.; 10.1113/jphysiol.2008.166033.
Atkin, J.D., et al. (2006) J. Biol. Chem. 281: 30153-30165.
Pietri M. et al. (2006) J. Biol. Chem. 281: 28470-28479.
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