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Product Details
| Cat # +Size | 3004-100 |
|---|---|
| Size | 100 µg |
| Alternate Name | CPP32 ,CASP3, apopain, procaspase3,CPP32B,SCA-1,CPP-32,Apopain,Yama |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse IgG1 |
| Immunogen | Recombinant human Caspase-3 |
| Accession # | P42574 |
| Gene ID | 836 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (200 µg/ml) in PBS containing 50% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). The antibody recognizes both proform and the cleaved large fragment of caspase-3 in samples of human, mouse and rat origins. However, the optimal conditions should be determined individually. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein among caspase family members. Caspase-3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP and DFF).
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Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
Schwartz, J. et al. Francisella tularensis Inhibits the Intrinsic and Extrinsic Pathways To Delay Constitutive Apoptosis and Prolong Human Neutrophil Lifespan, J. Immunol., Apr 2012; 188: 3351 - 3363.
Anand, S. et. al. Vitamin D3 Enhances the Apoptotic Response of Epithelial Tumors to Aminolevulinate-Based Photodynamic Therapy. Cancer Res., Sep 2011; 71: 6040 - 6050.
Chiou, S.K. et al. Suppression of Growth Arrest and DNA Damage-Inducible 45{alpha} Expression Confers Resistance to Sulindac and Indomethacin-Induced Gastric Mucosal Injury. J. Pharmacol. Exp. Ther., Sep 2010; 334: 693 - 702.
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