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Caspase-3 Antibody (Clone C33)

based on 6 citations in multiple journalsCaspase-3 Antibody (Clone C33)64.1 4
Catalog #: 3004
$310.00

Product Details

Cat # +Size 3004-100
Size 100 µg
Alternate Name CPP32 ,CASP3, apopain, procaspase3,CPP32B,SCA-1,CPP-32,Apopain,Yama
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Recombinant human Caspase-3
Accession # P42574
Gene ID 836
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (200 µg/ml) in PBS containing 50% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). The antibody recognizes both proform and the cleaved large fragment of caspase-3 in samples of human, mouse and rat origins. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein among caspase family members. Caspase-3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP and DFF).


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Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
Xie, Jing et al. (2017) Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone, Oncol Lett. 2017 Jun;13(6):4413-4419.
Schwartz, J. et al. Francisella tularensis Inhibits the Intrinsic and Extrinsic Pathways To Delay Constitutive Apoptosis and Prolong Human Neutrophil Lifespan, J. Immunol., Apr 2012; 188: 3351 - 3363.
Anand, S. et. al. Vitamin D3 Enhances the Apoptotic Response of Epithelial Tumors to Aminolevulinate-Based Photodynamic Therapy. Cancer Res., Sep 2011; 71: 6040 - 6050.
Chiou, S.K. et al. Suppression of Growth Arrest and DNA Damage-Inducible 45{alpha} Expression Confers Resistance to Sulindac and Indomethacin-Induced Gastric Mucosal Injury. J. Pharmacol. Exp. Ther., Sep 2010; 334: 693 - 702.
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