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Caspase-2 Substrate VDVAD-pNA

based on 3 citations in multiple journalsCaspase-2 Substrate VDVAD-pNA34.1 4
A caspase-2 substrate
Catalog #: 1072
SKU-Size Size Price Qty
1072-200 200 assays
1072-1000 1000 assays
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Product Details

Alternate Name Ac-VDVAD-pNA, Caspase-2 Substrate, Colorimetric, VDVAD-pNA
Peptide Sequence Ac-Val-Asp-Val-Ala-Asp-pNA
Appearance Liquid
Formulation DMSO (4 mM)
Molecular Formula C₂₉H₄₁N₇O₁₂
Molecular Weight 679.7
Purity >98% by HPLC
SMILES CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C
InChi InChI=1S/C29H41N7O12/c1-13(2)23(31-16(6)37)29(46)34-20(12-22(40)41)27(44)35-24(14(3)4)28(45)30-15(5)25(42)33-19(11-21(38)39)26(43)32-17-7-9-18(10-8-17)36(47)48/h7-10,13-15,19-20,23-24H,11-12H2,1-6H3,(H,30,45)(H,31,37)(H,32,43)(H,33,42)(H,34,46)(H,35,44)(H,38,39)(H,40,41)
PubChem CID 44135308
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ready-to-use colorimetric substrate for caspase-2/Ich-1 and related caspases that recognize the amino acid sequence VDVAD. Caspase-2 and related caspase activity can be quantified by detection of free pNA after cleavage from the peptide substrate VDVAD-pNA at OD405 nm using a spectrophotometer or plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase assays.

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Basu A et al (2008) Cancer Res. 68: 2795-3802.
Lee S-Y et al. (2007) Infect Immun. 75: 1291-1302.
Doostzadeh J., et al. (2000) J. Biol. Chem. 275:25336-25341.
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