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Caspase-2 Substrate VDVAD-AFC

based on 4 citations in multiple journalsCaspase-2 Substrate VDVAD-AFC44.1 4
A caspase-2 substrate
Catalog #: 1071
SKU-Size Size Price Qty
1071-200 200 assays
1071-1000 1000 assays
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Product Details

Alternate Name Ac-VDVAD-AFC, Caspase-2 Substrate, Fluorogenic, VDVAD-AFC, caspase2 substrate, caspase 2 substrate
Peptide Sequence Ac-Val-Asp-Val-Ala-Asp-AFC
Appearance Liquid
Formulation DMSO ( 1 mM)
Molecular Formula C₃₃H₄₁F₃N₆O₁₂
Molecular Weight 770.7
Purity >98% by HPLC
InChi InChI=1S/C33H41F3N6O12/c1-13(2)26(38-16(6)43)32(53)41-21(12-24(46)47)30(51)42-27(14(3)4)31(52)37-15(5)28(49)40-20(11-23(44)45)29(50)39-17-7-8-18-19(33(34,35)36)10-25(48)54-22(18)9-17/h7-10,13-15,20-21,26-27H,11-12H2,1-6H3,(H,37,52)(H,38,43)(H,39,50)(H,40,49)(H,41,53)(H,42,51)(H,44,45)(H,46,47)
PubChem CID 44135100
MDL Number MFCD04037014
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ready-to-use fluorometric substrate for caspases that recognize the amino acid sequence VDVAD. Caspase activity can be quantified by fluorescent detection of free AFC after cleaved from the peptide substrate VDVAD-AFC at Ex/Em = 400/505 nm using a fluorometer or a fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized using a hand-held long-UV lamp. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amount of caspase assays. Cell Lysis Buffer (Cat.# 1067-100), 2X Reaction Buffer (Cat.# 1068-20), DTT (Cat.# 1201-1), and other reagents used for caspase activity assays are also available separately.

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Basu A et al (2008) Cancer Res. 68: 2795-3802.
Ray, D. M., et al. (2005) J. Immunol. 174: 4060-4069.
Bai, S., et al. (2004) Am. Cancer Ther. 3:613-620.
Li, J., et al. (2002) J. Biol. Chem. 277:49504-49510.
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