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Product Details
| Alternate Name | Z-VDVAD-FMK, Caspase-2 Inhibitor, Z-VDVAD-fluoromethylketone |
|---|---|
| Peptide Sequence | Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK |
| Appearance | Liquid |
| Formulation | 1073-100 In DMSO (2 mM); 1073-20C In DMSO (10 mM) |
| Molecular Formula | C₃₂H₄₆FN₅O₁₁ |
| Molecular Weight | 695.7 |
| Purity | >98% by HPLC |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46) |
| InChi Key | ANTIWMNLIROOQF-UHFFFAOYSA-N |
| PubChem CID | 44135215 |
| MDL Number | MFCD03452881 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits caspase-2 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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Chun-Chen Chen et al., Coenzyme Q10 Rescues Ethanol-induced Corneal Fibroblast Apoptosis through the Inhibition of Caspase-2 Activation. J. Biol. Chem., Apr 2013; 288: 11689 - 11704.
Gillet, L. (2005) Cancer Res. 65: 9463-9472.
Yen, C.E., et al., (2002) J. Nutr. 132:1840-1847.
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