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Caspase-2, human recombinant

based on 4 citations in multiple journalsCaspase-2, human recombinant44.1 4
A cysteine protease involved in apoptosis 
Catalog #: 1082
SKU-Size Size Price Qty
1082-25 25 units
$215.00
1082-100 100 units
$365.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-2, CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, Protease ICH-1
Gene Symbol CASP2
Gene ID 835
Accession # P42575
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Molecular Weight two large (19 kDa) and two small (12 kDa) subunits
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-2 (also know as Ich-1, Nedd-2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed active caspase-2 is a heterotetramer consisting of two large (19 kDa) and two small (12 kDa) subunits.The recombinant active human caspase-2 was expressed in E. coli. The active caspase-2 preferentially cleaves caspase-2 substrates (e.g., VDVAD-AFC or VDVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-VDVAD-pNA (Cat. #1072-200) or Ac-VDVAD-AFC (1071-200).


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Shresh Pathak, Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro. JCI Insight., Feb. 2020;  32051334.
Murakami, E. et. al. Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. J. Biol. Chem., Nov 2010; 285: 34337 - 34347.
Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
Hasegawa H et al. (2007) Blood 110: 1664-1674.
Basu A., et al. (2002) J. Biol. Chem. 277:41850-41856.
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