Caspase-13 Substrate LEED-AFC

A caspase-13 substrate
Catalog #: 1116 | abID:

Product Details

Alternate Name Ac-LEED-AFC, Caspase-13 Substrate, Fluorogenic
Peptide Sequence Ac-Leu-Glu-Glu-Asp-AFC
Appearance Liquid
Formulation DMSO (4 mM)
Molecular Formula C₃₂H₃₈F₃N₅O₁₃
Molecular Weight 757.66
Purity >98% by HPLC
InChi InChI=1S/C32H38F3N5O13/c1-14(2)10-21(36-15(3)41)31(52)39-19(6-8-24(42)43)28(49)38-20(7-9-25(44)45)29(50)40-22(13-26(46)47)30(51)37-16-4-5-17-18(32(33,34)35)12-27(48)53-23(17)11-16/h4-5,11-12,14,19-22H,6-10,13H2,1-3H3,(H,36,41)(H,37,51)(H,38,49)(H,39,52)(H,40,50)(H,42,43)(H,44,45)(H,46,47)
PubChem CID 44135106
MDL Number MFCD03452816
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ready-to-use fluorometric substrate for caspase-13 and related caspases that recognize the amino acid sequence LEED. Caspase-13 and related caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the peptide substrate LEED-AFC at Ex. = 400 nm and Em. = 505 nm, using a fluorometer or multi-well fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized using a hand-held long-UV lamp.

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Baumgartner HK et al. (2007) Am. J. Physiol. Gastrointest. Liver Physiol. 293: G296-G307.
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