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Product Details
| Alternate Name | Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone) |
|---|---|
| Peptide Sequence | Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK |
| Appearance | Liquid |
| Formulation | 1115-100 In DMSO (2 mM); 1115-20C In DMSO (10 mM) |
| Molecular Formula | C₃₂H₄₅FN₄O₁₂ |
| Molecular Weight | 696.7 |
| Purity | >95% by HPLC |
| SMILES | CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CCC(=O)OC)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| InChi | InChI=1S/C32H45FN4O12/c1-19(2)15-24(37-32(45)49-18-20-9-7-6-8-10-20)31(44)35-21(11-13-26(39)46-3)29(42)34-22(12-14-27(40)47-4)30(43)36-23(25(38)17-33)16-28(41)48-5/h6-10,19,21-24H,11-18H2,1-5H3,(H,34,42)(H,35,44)(H,36,43)(H,37,45) |
| InChi Key | JQWJGEBRHHCICO-UHFFFAOYSA-N |
| PubChem CID | 44135223 |
| MDL Number | MFCD03453602 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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Bian, Y. et al. Neuregulin-1 Attenuated Doxorubicin-Induced Decrease in Cardiac Troponins. Am. J. Physiol. Heart Circ. Physiol. 2009; 297: H1974-H1983.
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