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Caspase-13 Inhibitor LEED-FMK

based on 1 citations in multiple journalsCaspase-13 Inhibitor LEED-FMK14.1 4
A caspase-13 inhibitor
Catalog #: 1115
SKU-Size Size Price Qty
1115-20C 20 µl (10 mM)
$125.00
1115-100 100 µl (2 mM)
$125.00
More Sizes Get Quote

Product Details

Alternate Name Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK
Appearance Liquid
Formulation 1115-100 In DMSO (2 mM); 1115-20C In DMSO (10 mM)
Molecular Formula C₃₂H₄₅FN₄O₁₂
Molecular Weight 696.7
Purity >95% by HPLC
SMILES CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CCC(=O)OC)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C32H45FN4O12/c1-19(2)15-24(37-32(45)49-18-20-9-7-6-8-10-20)31(44)35-21(11-13-26(39)46-3)29(42)34-22(12-14-27(40)47-4)30(43)36-23(25(38)17-33)16-28(41)48-5/h6-10,19,21-24H,11-18H2,1-5H3,(H,34,42)(H,35,44)(H,36,43)(H,37,45)
InChi Key JQWJGEBRHHCICO-UHFFFAOYSA-N
PubChem CID 44135223
MDL Number MFCD03453602
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Bian, Y. et al. Neuregulin-1 Attenuated Doxorubicin-Induced Decrease in Cardiac Troponins. Am. J. Physiol. Heart Circ. Physiol. 2009; 297: H1974-H1983.
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