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Caspase-12 Inhibitor Z-ATAD-FMK

based on 6 citations in multiple journalsCaspase-12 Inhibitor Z-ATAD-FMK64.1 4
A caspase-12 inhibitor
Catalog #: 1079
SKU-Size Size Price Qty
1079-20C 20 µl (10 mM)
1079-100 100 µl (2 mM)
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Product Details

Alternate Name Z-ATAD-FMK, Caspase-12 Inhibitor, Z-ATAD-fluoromethylketone
Peptide Sequence Z-Ala-Thr-Ala-Asp(OMe)-FMK
Appearance Liquid
Formulation 1079-100 In DMSO (2 mM); 1079-20C In DMSO (10 mM)
Molecular Formula C₂₄H₃₃FN₄O₉
Molecular Weight 540.54
Purity >95% by HPLC
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A synthetic peptide that irreversibly inhibits caspase-12 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

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What is the mechanism of inhibition of caspase 12 by Caspase-12 Inhibitor Z-ATAD-FMK?
Z-ATAD-FMK is a synthetic peptide that irreversibly inhibits caspase-12.  It also suppresses annular cell apoptosis and caspase-9 activity in vitro.