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Caspase-12 Antibody

based on 3 citations in multiple journalsCaspase-12 Antibody34.1 4
Catalog #: 3282
SKU-Size Size Price Qty
3282-30T 30 µg
$89.00
3282-100 100 µg
$280.00
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Product Details

Antibody Target Caspase -12
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding amino acid 310 of mouse caspase-12
Accession # NM_009808
Gene ID 12364
Appearance Colorless liquid
Concentration 0.2 mg/ml
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-12 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). It detects procaspase-12 (55 kDa) and cleavage caspase-12 (36 kDa) on SDS-PAGE immunoblots. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains two pathways, in which the key apoptotic proteases caspase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is located to the ER, but not to the cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium hemeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and β-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-β. Caspase-12 is ubiquitously expressed in mouse tissues.


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Lin ,Ying et al. (2016) Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress‑induced macrophage apoptosis in apoE‑/‑ mice, Mol Med Rep. 2016 Feb;13(2):1509-16.
French JP et al (2008) FASEB J, 101096/fj.07-102541.
Chin T-Y et al. (2007)Am J. Physiol Cell Physiol. 292: C383-C395.
Huang C-J et al. (2007)Am. J. Physiol. Endocrinol Metab. 10.1152/aipendo.00318.2007.
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