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Caspase-10 Inhibitor AEVD-FMK

based on 6 citations in multiple journalsCaspase-10 Inhibitor AEVD-FMK64.1 4
A caspase-10 inhibitor
Catalog #: 1112
SKU-Size Size Price Qty
1112-20C 20 µl (10 mM)
$125.00
1112-100 100 µl (2 mM)
$125.00
More Sizes Get Quote

Product Details

Alternate Name Z-AEVD-FMK, Caspase-10 Inhibitor (fluoromethylketone)
Peptide Sequence Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK
Appearance Liquid
Formulation 1112-100 In DMSO (2 mM); 1112-20C In DMSO (10 mM)
Molecular Formula C₂₈H₃₉N₄O₁₀F
Molecular Weight 610.63
Purity >95% by HPLC
SMILES CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1
InChi InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)
InChi Key CHZRBQFKZDGMTP-UHFFFAOYSA-N
PubChem CID 44135225
MDL Number MFCD03453601
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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Appelqvist et al., Lysosomal exocytosis and caspase-8-mediated apoptosis in UVA-irradiated keratinocytes. J. Cell Sci., Dec 2013; 126: 5578 - 5584.
Westphal, D. et. al. Clustering of the Neural Cell Adhesion Molecule (NCAM) at the Neuronal Cell Surface Induces Caspase-8- and -3-dependent Changes of the Spectrin Meshwork Required for NCAM-mediated Neurite Outgrowth. J. Biol. Chem., Dec 2010; 285: 42046 - 42057.
klumpp D.J. et al. (2006) Infect. Immun. 74: 5106-5113.
Gillet, L. (2005) Cancer Res. 65: 9463-9472.
Ruckdeschel, K., et al. (2002) J. Immunol. 168:4601-4611.
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