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Product Details
| Alternate Name | Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4 |
|---|---|
| Source | E. coli. |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | two large (18 kDa) and two small (11 kDa) subunits in a heterotetramer form. |
| Purity by SDS-PAGE | ≥90% |
| Reconstitution Instructions | Reconstitute to 1 unit per μl in PBS containing 15% glycerol. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -70°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Caspase-10b (also known as FLICE 2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-10 also exists in cells as an inactive proenzyme. During apoptosis procaspase-10 is processed at aspartate residues to form active caspase-10 which consists of two large (18 kDa) and two small (11 kDa) subunits in a heterotetramer form. The recombinant active human caspase-10/b was expressed in E. coli. The active caspase-10 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).
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Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
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