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Caspase-10/b, human recombinant

A cysteine protease involved in apoptosis 
Catalog #: 1090B
SKU-Size Size Price Qty
1090B-25 25 units
$205.00
1090B-100 100 units
$345.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized powder
Molecular Weight two large (18 kDa) and two small (11 kDa) subunits in a heterotetramer form.
Purity by SDS-PAGE ≥90%
Reconstitution Instructions Reconstitute to 1 unit per μl in PBS containing 15% glycerol.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-10b (also known as FLICE 2) is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-10 also exists in cells as an inactive proenzyme. During apoptosis procaspase-10 is processed at aspartate residues to form active caspase-10 which consists of two large (18 kDa) and two small (11 kDa) subunits in a heterotetramer form. The recombinant active human caspase-10/b was expressed in E. coli. The active caspase-10 is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-IETD-pNA (Cat. #1063-200) or Ac-IETD-AFC (1062-200).


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Chen H et al (2009) Mol. Cell. Biol.; 29: 3657 - 3664.
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