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Product Details
| Alternate Name | Ac-YVAD-pNA, Caspase-1 Substrate, Colorimetric |
|---|---|
| Peptide Sequence | Ac-Tyr-Val-Ala-Asp-pNA |
| Appearance | Liquid |
| Formulation | DMSO (4 mM) |
| Molecular Formula | C₂₉H₃₆N₅O₁₀ |
| Molecular Weight | 628.6 |
| Purity | >98% by HPLC |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C |
| InChi | InChI=1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1 |
| InChi Key | YDPNOCSPPGFBPX-XNHCRPTKSA-N |
| PubChem CID | 10484117 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Ready-to-use colorimetric substrate for caspase-1/ICE and related caspases that recognize the amino acid sequence YVAD. Caspase-1 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate YVAD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for large volume users.
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Oh, H. A. et. al. Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro. J. Pharmacol. Exp. Ther., Oct 2011; 339: 72 - 81.
Doostzadeh J., et al. (2000) J. Biol. Chem. 275:25336-25341.
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