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Product Details
| Alternate Name | Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone |
|---|---|
| Peptide Sequence | Z-Tyr-Val-Ala-Asp(OMe)-FMK |
| Appearance | Liquid |
| Formulation | 1012-100 In DMSO (2 mM); 1012-20C In DMSO (10 mM) |
| Molecular Formula | C₃₁H₃₉FN₄O₉ |
| Molecular Weight | 630.7 |
| Purity | >99% by HPLC |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2 |
| InChi | InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1 |
| InChi Key | MVPQJUFFTWWKBT-UYDLRUHXSA-N |
| PubChem CID | 16760349 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A synthetic peptide that irreversibly inhibits ICE (interleukin-1β converting enzyme, Ki = 0.76 nM) activity. YVAD is the preferred recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
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Arai S et al. (2007) PNAS 104: 2289-2294.
Klumpp D.J. et al. (2006) Infect. Immun. 74: 5106-5113.
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