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Caspase-1 Inhibitor Z-YVAD-FMK

based on 9 citations in multiple journalsCaspase-1 Inhibitor Z-YVAD-FMK94.1 4
Caspase-1 inhibitor
Catalog #: 1012

In stock

SKU-Size Size Price Qty
1012-20C 20 µl (10 mM)
$135.00
1012-100 100 µl (2 mM)
$135.00
More Sizes Get Quote

Product Details

Alternate Name Z-YVAD-FMK, Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
Peptide Sequence Z-Tyr-Val-Ala-Asp(OMe)-FMK
Appearance Liquid
Formulation 1012-100 In DMSO (2 mM); 1012-20C In DMSO (10 mM)
Molecular Formula C₃₁H₃₉FN₄O₉
Molecular Weight 630.7
Purity >99% by HPLC
SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2
InChi InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1
InChi Key MVPQJUFFTWWKBT-UYDLRUHXSA-N
PubChem CID 16760349
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A synthetic peptide that irreversibly inhibits ICE (interleukin-1β converting enzyme, Ki = 0.76 nM) activity. YVAD is the preferred recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).


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L'homme et al., Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J. Lipid Res., Nov 2013; 54: 2998 - 3008.
Hewison J et al (2008) J. Immunol. 180: 8410 - 8420.
Cruz VM et al. (2007) J. Biol. Chem . 282: 2871-2879.
Arai S et al. (2007) PNAS 104: 2289-2294.
Klumpp D.J. et al. (2006) Infect. Immun. 74: 5106-5113.
For more citations of this product click here