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Caspase-1, human recombinant

based on 9 citations in multiple journalsCaspase-1, human recombinant94.1 4
A cysteine protease involved in apoptosis 
Catalog #: 1081
SKU-Size Size Price Qty
1081-25 25 units
$220.00
1081-100 100 units
$375.00
More Sizes Get Quote

Product Details

Alternate Name Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, IL-1 beta-converting enzyme, p45
Gene Symbol CASP1
Gene ID 834
Accession # NP_150634.1
Source E. coli.
Appearance Semi-Dry powder
Physical Form Description Lyophilized powder
Molecular Weight large (20 kD) and small (10 kD) subunitsk
Reconstitution Instructions Reconstitute to 1 unit per µl in water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Caspase-1 (also know as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kD) and small (10 kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant active human caspase-1 was expressed in E. coli. The active caspase-1 preferentially cleaves caspase-1 substrates (e.g., YVAD-AFC or YVAD-pNA) and is routinely tested at BioVision for its ability to enzymatically cleave these two substrates Ac-YVAD-pNA (Cat. #1104-200) or Ac-YVAD-AFC (1103-200). The rh-Caspase has an N-term His-tag and corresponds to amino acids 120-404 of Caspase-1, gene accession# NP_150634.1.


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Shresh Pathak, Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro. JCI Insight., Feb. 2020;  32051334.
Ahn, Huijeong et al. (2017) Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation, Phytomedicine. 2017 Jan 15;24:77-86.
Kim, Hee-Yun et al. (2016) 2-(4-{2 [(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide as a new lead compound for management of allergic rhinitis, Inflamm Res. 2016 Dec;65(12):963-973.
Han et al., The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP. Experimental Biology and Medicine, Apr 2014; 239: 454 - 464.
Oh, H. A. et. al. Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro. J. Pharmacol. Exp. Ther., Oct 2011; 339: 72 - 81.
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