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Caspase-1 Antibody

based on 3 citations in multiple journalsCaspase-1 Antibody34.1 4
Catalog #: 3019
SKU-Size Size Price Qty
3019-30T 30 µg
$105.00
3019-100 100 µg
$340.00
More Sizes Get Quote

Product Details

Antibody Target Caspase-1
Alternate Name CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 132 of human caspase-1
Accession # NP_150636
Gene ID 834
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.5 mM EDTA, 0.03% ProClin®
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunoprecipitation, Immunofluorescence
Application & Usage Western blot analysis (0.5-4 µg/ml), immunoprecipitation (4-8 µg/ml) and immunofluorescence (10-20 µg/ml). The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.


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Shi, X. et. al. Neuropeptides Contribute to Peripheral Nociceptive Sensitization by Regulating Interleukin-1β Production in Keratinocytes. Anesth. Analg., Jul 2011; 113: 175 - 183.
Peluffo M.C. et al (2006) Reproduction 132: 465-475.
Sasaki M. et al. (2006) Am. J. Path. 169: 831-845.
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