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Caspase 1 Antibody

Polyclonal Antibody to detect Caspase 1 in human samples
Catalog #: 6687
SKU-Size Size Price Qty
6687-30T 30 µg
$89.00
6687-100 100 μg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Caspase 1
Alternate Name CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Mouse Recombinant Caspase 1, Cat # 1181
Accession # P29452
Gene ID 12362
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Purification Affinity Purified Antibody
Species Reactivity Human, Mouse
Application Western blot
Positive Control Western Blot: Jurkat cell lysate, mouse muscle lysate, recombinant protein
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form.


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