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Carmofur

An acid ceramidase inhibitor
Catalog #: B2448
SKU-Size Size Price Qty
B2448-50 50 mg
$65.00
B2448-250 250 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name HCFU, 5-fluoro-N-hexyl-3,4-dihydro-2H,4-dioxo-1-pyrimidinecarboxamide
Appearance White solid
CAS # 61422-45-5
Molecular Formula C₁₁H₁₆FN₃O₃
Molecular Weight 257.27
Purity ≥98%
Solubility ~20 mg/ml in DMSO
SMILES CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
InChi InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChi Key AOCCBINRVIKJHY-UHFFFAOYSA-N
PubChem CID 2577
MDL Number MFCD00866284
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Carmofur is derivative of 5-flurouracil (Cat. No. B1519) that acts as an inhibitor of acid ceramidase (IC₅₀ = 79 nM for the rat enzyme). It reduces acid ceramidase activity in a dose- and time-dependent manner. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC₅₀ = 1,212 mM for human thymidylate synthetase).


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