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Carbonic Anhydrase (CA) Inhibitor Screening Kit (Colorimetric)

High-throughput compatible, quick and easy screening for Carbonic Anhydrase ligands; Includes human recombinant NEP
Catalog #: K473

Product Details

Cat # +Size K473-100
Size 100 assays
Detection Method Colorimetric (OD 405 nm)
Applications Screening of drugs and novel ligands for interaction with human recombinant Carbonic Anhydrase.
Features & Benefits • Simple, highly sensitive, high-throughput compatible
• Rapid screening of Carbonic Anhydrase ligands
• Kit includes Acetazolamide, a CA inhibitor, and a stable, recombinant human CA
Kit Components • CA Assay Buffer
• CA Dilution Probe
• CA Enzyme
• CA Substrate
• CA Inhibitor (2 mM Acetazolamide)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Carbonic anhydrases (CA; EC: are zinc enzymes present in both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of CO2 to bicarbonate. Their important patho-physiological roles in respiration, pH and CO2 homeostasis, secretion, gluconeogenesis, ureagenesis etc. make it an important drug target. CA inhibition in different organs can result in different effects. Inhibition of CA helps in different disease treatment procedures; for example, it can help in the treatment of Glaucoma, urine alkalization, managing epilepsy, sleep apnea, acute mountain sickness etc. BioVision’s CA Inhibitor Screening Kit can be used to screen for potent inhibitors of CA activity. It utilizes the esterase activity of an active CA on an ester substrate which releases a chromogenic product. The released product can be easily quantified using an absorbance microplate reader. In the presence of a CA specific inhibitor, the enzyme loses its activity which results in decrease of absorbance. This assay kit is simple and can be used to identify and characterize CA inhibitors in a high-throughput format. Here, we have used the specific inhibitor Acetazolamide, a potent inhibitor of CA I, CA II, CA IV, CA IX, CA XII etc. except CA III

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