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Carbonic anhydrase-8, human recombinant

A protein lacks carbonic anhydrase activity, involved in Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3).
Catalog #: P1047

In stock

SKU-Size Size Price Qty
P1047-10 10 μg
$105.00
P1047-50 50 μg
$305.00
More Sizes Get Quote

Product Details

Alternate Name CA-VIII, CALS, CAMRQ3, CARP, CA8
Gene Symbol CA8
Gene ID 767
Accession # P35219
Source E. coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 20% glycerol
Molecular Weight 35.5 kDa
Purity by SDS-PAGE > 90%
Biological Activity Specific activity is defined as the amount of enzyme that hydrolyze 1.0 pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH 7.5 at 37C.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSHMADLSF IEDTVAFPEK EEDEEEEEEG VEWGYEEGVE WGLVFPDANG EYQSPINLNS REARYDPSLL DVRLSPNYVV CRDCEVTNDG HTIQVILKSK SVLSGGPLPQ GHEFELYEVR FHWGRENQRG SEHTVNFKAF PMELHLIHWN STLFGSIDEA VGKPHGIAII ALFVQIGKEH VGLKAVTEIL QDIQYKGKSK TIPCFNPNTL LP
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CA8 was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, this protein lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). It continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). Recombinant human CA8 protein fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.


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