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An ATP competitive inhibitor of c-MET kinase
Catalog #: B3005
SKU-Size Size Price Qty
B3005-5 5 mg
B3005-25 25 mg
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Product Details

Alternate Name INC280; INCB28060; INC28060; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
Appearance Yellow solid powder
CAS # 1029712-80-8
Molecular Formula C₂₃H₁₇FN₆O
Molecular Weight 412.4
Purity >98%
Solubility ~0.3 mg/ml in DMSO, ~1 mg/ml in DMF
InChi InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
PubChem CID 25145656
MDL Number MFCD18633285
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream pathways. Capmatinib potently inhibits in vitro kinase activity with an IC₅₀ of 0.13 nM. It prevents HGF-stimulated H441 cell migration with an IC₅₀ value of a ~2 nM. It inhibts c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models.

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