Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Capmatinib

An ATP competitive inhibitor of c-MET kinase
Catalog #: B3005
SKU-Size Size Price Qty
B3005-5 5 mg
$75.00
B3005-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name INC280; INCB28060; INC28060; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
Appearance Yellow solid powder
CAS # 1029712-80-8
Molecular Formula C₂₃H₁₇FN₆O
Molecular Weight 412.4
Purity >98%
Solubility ~0.3 mg/ml in DMSO, ~1 mg/ml in DMF
SMILES CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
InChi InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChi Key LIOLIMKSCNQPLV-UHFFFAOYSA-N
PubChem CID 25145656
MDL Number MFCD18633285
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream pathways. Capmatinib potently inhibits in vitro kinase activity with an IC₅₀ of 0.13 nM. It prevents HGF-stimulated H441 cell migration with an IC₅₀ value of a ~2 nM. It inhibts c-MET phosphorylation and tumor growth in c-MET-driven mouse tumor models.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.