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based on 6 citations in multiple journalsCamptothecin64.1 4
A topoisomerase I inhibitor
Catalog #: 1039
SKU-Size Size Price Qty
1039-1 1 ml
1039-50MG 50 mg
1039-500MG 500 mg
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Product Details

Alternate Name (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione
Appearance • Liquid
• Solid
Formulation • 1039-1 (2 mg/ml in DMSO)
• 1043-25MG (Solid)
• 1043-250MG (Solid)
CAS # 7689-03-4
Molecular Formula C₂₀H₁₆N₂O₄
Molecular Weight 348.4
Purity >98% by TLC
InChi InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
PubChem CID 24360
MDL Number MFCD00081076
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.

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Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
Berger, B. et al. Defective p53 antiangiogenic signaling in glioblastoma. Neuro Oncology, Sep 2010; 12: 894 - 907.
Jensen H et al (2009) J. Leukoc. Biol.; 10.1189/jlb.0209056.
Bull TM et al (2008) Am. J. Respir. Cell Mol. Biol.; 39: 706 - 716.
Hirai Y et al. (2007) J. Cell Sci. 120: 2032-2043.
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