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Cambinol

A SIRT1 inhibitor
Catalog #: 1653

In stock

$185.00

Product Details

Cat # +Size 1653-10
Size 10 mg
Alternate Name 5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; NSC-112546
Appearance White solid
CAS # 14513-15-6
Molecular Formula C₂₁H₁₆N₂O₂S
Molecular Weight 360.43
Purity ≥95% by HPLC
Solubility DMSO (10 mg/ml)
SMILES C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
InChi InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
InChi Key RVNSQVIUFZVNAU-UHFFFAOYSA-N
PubChem CID 3246390
MDL Number MFCD09057543
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC₅₀ = 56 µM) and SIRT2(IC₅₀ = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.


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