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Calreticulin, human recombinant

Involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity
Catalog #: 7570
SKU-Size Size Price Qty
7570-10 10 μg
$290.00
7570-50 50 μg
$975.00
More Sizes Get Quote

Product Details

Alternate Name CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
Gene Symbol CALR
Gene ID 811
Accession # P27797
Source E. coli
Appearance Liquid
Physical Form Description 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Molecular Weight ~55.0 kDa. Human calreticulin (aa 18-417) is fused at the C-terminus to a His-tag.
Purity by SDS-PAGE ≥90%
Endotoxin Level <0.1 EU/μg by LAL method
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.


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