Product Details
| Alternate Name | (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl esterUCN 1028C; PKF115-584; Cal-C |
|---|---|
| Appearance | Dark red solid |
| CAS # | 121263-19-2 |
| Molecular Formula | C₄₄H₃₈O₁₄ |
| Molecular Weight | 790.76 |
| Purity | >95% by HPLC |
| Solubility | DMSO or EtOH |
| SMILES | CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7 |
| InChi | InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3 |
| InChi Key | LSUTUUOITDQYNO-UHFFFAOYSA-N |
| PubChem CID | 2533 |
| MDL Number | MFCD00133155 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent and highly specific cell-permeable protein kinase C (PKC) inhibitor . The inhibition of PKC is light-dependent. Also inhibits PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src . Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Shown to directly and potently block L-type calcium channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Also Wnt/β-catenin/lef-1 signaling inhibitor.
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