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Calpain Inhibitor II, ALLM

A Calpain inhibitor
Catalog #: 1835
SKU-Size Size Price Qty
1835-5 5 mg
$100.00
1835-25 25 mg
$415.00
More Sizes Get Quote

Product Details

Alternate Name Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional
Appearance White powder
CAS # 136632-32-1
Molecular Formula C₁₉H₃₅N₃O₄S
Molecular Weight 401.57
Purity ≥95% by HPLC
Solubility DMSO (25 mg/ml) or EtOH (25 mg/ml)
SMILES CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C
InChi InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)
InChi Key RJWLAIMXRBDUMH-UHFFFAOYSA-N
PubChem CID 4331
MDL Number MFCD00065506
Handling Protect from moisture and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.


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