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Product Details
| Alternate Name | Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional |
|---|---|
| Appearance | White powder |
| CAS # | 136632-32-1 |
| Molecular Formula | C₁₉H₃₅N₃O₄S |
| Molecular Weight | 401.57 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (25 mg/ml) or EtOH (25 mg/ml) |
| SMILES | CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C |
| InChi | InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26) |
| InChi Key | RJWLAIMXRBDUMH-UHFFFAOYSA-N |
| PubChem CID | 4331 |
| MDL Number | MFCD00065506 |
| Handling | Protect from moisture and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
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