Product Details
| abID | ab141445 |
|---|---|
| Alternate Name | Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al |
| Appearance | White powder |
| CAS # | 110044-82-1 |
| Molecular Formula | C₂₀H₃₇N₃O₄ |
| Molecular Weight | 383.54 |
| Purity | ≥95% by HPLC |
| Solubility | DMSO (25 mg/ml) or EtOH |
| SMILES | CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C |
| InChi | InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1 |
| InChi Key | FMYKJLXRRQTBOR-BZSNNMDCSA-N |
| PubChem CID | 443118 |
| MDL Number | MFCD00065505 |
| Handling | Protect from moisture and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
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Cho et al., Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. PNAS, Aug 2014; 111: 12043 - 12048.
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