Product Details
| Antibody Target | Calnexin |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 580 of human Calnexin |
| Accession # | P27824 |
| Gene ID | 821 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat, dog |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~90-100 kDa band, corresponding to glycosylated Calnexin in samples from human, mouse, rat, and dog origins. Reactivity to other |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Calnexin (CNX) is a 90kDa integral protein of the endoplasmic reticulum (ER). Calnexin belongs among chaperones, which are characterized by their main function of assisting protein folding and quality control, ensuring that only properly folded and assembled proteins proceed further along the secretary pathway. The function of Calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum.
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Adu-Gyamfi et al., Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus. J. Virol., Sep 2015; 89: 9440 - 9453.
Bull et al .,Progressive Disorganization of Paranodal Junctions and Compact Myelin Due to Loss of DCC Expression by Oligodendrocytes. J. Neurosci., Jul 2014; 34: 9768 - 9778.
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