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Calcineurin A Antibody

Catalog #: 3075
SKU-Size Size Price Qty
3075-30T 30 µg
$89.00
3075-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Calcineurin A
Alternate Name PPP3CA, CCN1, CNA1, CALN, CALNA, CALNA1, PPP2B
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to residues surrounding amino acids 267 of human Calcineurin A
Accession # P16298
Gene ID 5532
Appearance Colorless liquid
Concentration 0.2 mg/ml
Purification Affinity purified
Species Reactivity Human, mouse, rat, hamster, rabbit, bovine
Application Western blot, Immunoprecipitation
Application & Usage Western Blotting (1-4 µg/ml) and for immunoprecipitation (10-20 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects a 61 kDa band, corresponding to the expected molecular weight of Calcin
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant drμgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.


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